Features and Benefits

• Antigenically unique, classic strain IBD virus
• Chicken embryo origin vaccine

Indications
For use in chickens at 1 day of age by subcutaneous route of administration or by drinking water at 2 weeks or older as an aid in preventing bursal disease associated with infection by standard and variant infectious bursal disease viruses. This is a restricted product. Use only in states where permitted and on premises with a histroy of bursal disease.

Contents:
A live virus vaccine containing a bursal disease virus derived from a field strain. The vaccine was attenuated by serial passage in cell culture and has been demonstrated in controlled studies to provide protection against standard and variant bursal disease viruses. The vaccine virus is grown in chicken embryos and combined with stabilizing agents. The product is supplied as a lyophilized vaccine contained in vials sealed under vacuum. Contains gentamicin as a preservative.

Dosage and Administration:
When to Vaccinate: Vaccinate subcutaneously at 1 day of age or by drinking water at 2 weeks or older. Good management practices should be followed to reduce exposure of birds to virulent infectious bursal disease virus during the first several weeks of life.

Preparation of the Vaccine:
Subcutaneous Route of Administration:
Do not open and mix the vaccine until ready for use.

Mix only one vial at a time and use entire contents within 2 hours.

Lift up top of seal on vaccine vial to expose rubber stopper. Using sterile needle and 5 or 10 mL syringe, remove a small amount (5 mL) of diluent from the diluent bottle and transfer this to the vaccine vial. Vacuum in the vaccine vial will readily pull in the diluent. Release the vacuum remaining in the vial.

Vigorously shake vaccine vial with transferred diluent to rehydrate the vaccine.

Using the same sterile needle and syringe, completely transfer the rehydrated vaccine to remaining diluent in the diluent bottle. Rinse syringe and vaccine vial by withdrawing additional diluent in diluent bottle. Rinse syringe and vaccine vial by withdrawing additional diluent and repeating the process.

Vigorously shake the final rehydrated vaccine for 20-30 seconds to mix thoroughly. The vaccine is now ready for use.

Drinking Water Method:
Assemble the vaccine and equipment needed to vaccinate the entire flock at one time.

Do not open and mix the vaccine until ready for use.

Remove the tear-off aluminum seal from the vaccine vial without disturbing the rubber stopper. Use cool, clean, non-chlorinated tap water to which powdered milk has been added as directed under How to Vaccinate.

Holding vial submerged in a pail of water or under a running stream of water, lift the top of the rubber stopper so that the water (milk added) is sucked into the vial. Reseat the stopper and shake the vial to thoroughly dissolve the vaccine.

How to Vaccinate:
By Subcutaneous Route of Administration:
Insert a filling tube (large, sharpened transfer tube) into the bottle of vaccine. Connect the filling tube by means of rubber or plastic tubing to an automatic vaccinator fitted with a 22 gauge � inch needle. The automatic vaccinator should be calibrated accurately ahead of time to deliver 0.2 mL.

By Drinking Water Method:
Do not mix the vaccine into the drinking water until ready for use. Drinking water for vaccination should be mixed with powdered milk to prevent inactivation from chlorine or other water additives and also to stabilize the vaccine virus. The powdered milk should be added to the water at a rate of 3 grams per 11 liters (one heaped teaspoon per 3 U.S. gallons or 2.5 Imp. gallons); or 90 grams per 300 liters (one heaped cupful per 80 gallons or 66 Imp. gallons).

Withhold water for several hours before vaccinating so birds are thirsty. Thoroughly clean and rinse all watering containers so that no residual disinfectants remain. Dilute the vaccine immediately before use with cool, clan, non-chlorinated water (milk added). Pour the dissolved vaccine material into the following amounts of water and mix thoroughly.

Each 1,000 birds	U.S Gallons	Imperial Gallons	Metric Liters
2 to 4 weeks	2.5	2	10
4 to 8 weeks	5	4	20
Over 8 weeks	10	8	40

Distribute diluted vaccine so that all birds are able to drink within a 1 hour period and do not add any more water until the vaccine is consumed. Avoid placing water in direct sunlight.

Records: Keep a record of vaccine type, quantity, serial number, expiration date, and place of purchase; the date and time of vaccination; the number, age, breed, and location of the birds; names of operators performing the vaccination and any observed reactions.

Precaution(s):
Store at 2� to 7�C (35� to 45�F).

Caution(s):
Use only in states where permitted and on premises with a history of bursal disease.

For subcutaneous use only in day old birds. For use by drinking water in birds 2 weeks or older.

All birds within a house should be vaccinated on the same day. Isolate other susceptible birds on the premises from birds being vaccinated.

Vaccinate only healthy birds. Although disease may not be evident, coccidiosis, chronic respiratory disease, mycoplasma infection, lymphoid leukosis, Marek's disease, or other disease conditions may cause serious complications or reduce protection.

In outbreak situations, vaccinate healthy birds first, progressing toward outbreak areas in order to vaccinate diseased birds last.

Warning(s):
Do not vaccinate within 21 days of slaughter.

Wash hands thoroughly after using the vaccine.

The use of this vaccine is subject to state laws wherever applicable.

For veterinary use only.

Discussion:
Vaccination Program: The development of a durable, strong protection against this disease depends upon the use of an effective vaccination program as well as many circumstances such as administration techniques, environment and flock health at time of vaccination. Also, the immune response to one vaccination under field conditions is seldom compete for all birds within a given flock. Even when vaccination is successful, the protection stimulated in individual animals against different diseases may not be life long. Therefore, a program of periodic revaccination may be necessary.

Presentation:
5000 dose vials.

Product information is also available in French and Spanish.