Nobilis® ND C2The gentle approach to Newcastle Disease protection.

Nobilis® ND C2 contains a novel respiratory Newcastle Disease strain that causes no vaccination reactions.

Live ND vaccines may cause vaccination reactions particularly following day old vaccination. Undesirable vaccination reactions result in decreased efficacy of the respiratory immune system. Birds are then susceptible to secondary bacterial infections.
This results in:

• Reduced growth rates
• Increased mortality
• Increased condemnations

Decreased overall production of the flock.

The Solution: Nobilis ND C2

Nobilis ND C2 vaccine is a live vaccine against Newcastle Disease in chickens. Active components per dose:

• Each vial contains 5.7 - 7.5 log10 EID50 per dose of live attenuated Newcastle disease virus (NDV) strain C2

A lyophilised pellet for reconstitution to a suspension for oculonasal or spray application Poultry. For active immunisation of chickens to reduce clinical signs and mortality caused by Newcastle disease virus. The vaccine can be administered to chickens from 1 day of age onwards.The optimum time and method of administration depend largely upon the local situation. Because of the mild nature of the C2 vaccine strain it is suitable for vaccination from 1 day of age onwards, and it is recommended to revaccinate after 2-3 weeks with a live lentogenic NDV vaccine (e.g. Nobilis ND Clone 30) to enhance the immunity. Administer 1 dose of at least 5.7 log10 EID50 per animal

• Oculonasal application
  Reconstitute the vaccine with the appropriate amount of a suitable diluent and administer by means of the standardised dropper. One drop should be applied onto one nostril or one eye. Ensure that the nasal drop is inhaled before freeing the bird. For oculonasal administration a special diluent, Nobilis Diluent O/N, is available in a dropper in two dosage forms (1000 and 2500 doses).
  
• Spray
  Reconstitute the vaccine in cool, clean water to which 2% skimmed milk may be added. The volume of diluent for reconstitution should be sufficient to ensure an even distribution when sprayed onto the birds. This will vary according to the age of the birds being vaccinated and the management system, but 250 to 500 ml of water per 1000 doses is suggested. The vaccine suspension should be spread evenly over the birds at a distance of 30-40 cm, preferably when the birds are sitting together in dim light. The spray apparatus should be free from sediments, corrosion and traces of disinfectants and ideally should be used for vaccination purposes only.

Zero days Cardboard box with 1 or 10 vials of glass (hydrolytic type II) with rubber stopper and metal cap.
Contents per vial:

• 1000, 2500 or 5000, doses

Freeze-dried vaccine: at 2-8�C in the dark.
Vaccine after reconstitution: ambient temperature / below 25�C
Transportation of the vaccine can be done at room temperature as it has been shown that this will not affect the quality of the vaccine.
Live Newcastle disease vaccines may cause a mild transient conjunctivitis in the person administering the vaccine. None. Dispose of empty or part-used vials in accordance with local regulations.